Two-headed PROTAC: an effective new tool for targeted protein degradation

Chembiochem. 2010 Jul 26;11(11):1531-4. doi: 10.1002/cbic.201000222.

Authors

Kedra Cyrus^#¹, Marie Wehenkel^#¹, Eun-Young Choi², Hollie Swanson², Kyung-Bo Kim¹

Affiliations

¹ Department of Pharmaceutical Sciences University of Kentucky 789 South Limestone, Lexington, KY 40536-0596, USA.
² Department of Molecular and Biomedical Pharmacology University of Kentucky 800 Rose Street, Lexington, KY 40536, USA hswan@uky.edu.

^# Contributed equally.

No abstract available

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Drug Delivery Systems
Female
Humans
Ligases
Peptides* / pharmacology
Protein Stability / drug effects
Proteins* / drug effects
Proteins* / metabolism
Receptors, Estrogen* / drug effects
Receptors, Estrogen* / metabolism

Substances

Ligases
Peptides
Proteins
Receptors, Estrogen

Grants and funding