Fresh-frozen plasma transfusion strategy in trauma with massive and ongoing bleeding. Common (sense) and sensibility

Resuscitation. 2010 Sep;81(9):1079-81. doi: 10.1016/j.resuscitation.2010.02.030. Epub 2010 Jun 22.


During trauma resuscitation involving massive transfusion, the best fresh-frozen plasma to packed red blood cells ratio is unknown. No randomised controlled trial (RCT) is available on this subject, although there are plenty of observational studies suggesting that the ratio should be about 1:1. This ratio also makes more physiological sense, and we suggest that in patients with massive and ongoing bleeding, it is a sensible strategy with which to start resuscitation.

Publication types

  • Evaluation Study

MeSH terms

  • Blood Component Transfusion / standards*
  • Erythrocyte Transfusion*
  • Hemorrhage / etiology
  • Hemorrhage / physiopathology*
  • Hemorrhage / therapy*
  • Humans
  • Plasma*
  • Resuscitation / methods*
  • Severity of Illness Index
  • Wounds and Injuries / complications*
  • Wounds and Injuries / physiopathology*