A highly convergent synthesis of tricyclic N-heterocycles coupling an Ugi reaction with a tandem S(N)2'-Heck double cyclization

Renata Riva; Luca Banfi; Andrea Basso; Valentina Cerulli; Giuseppe Guanti; Marcella Pani

doi:10.1021/jo100859y

A highly convergent synthesis of tricyclic N-heterocycles coupling an Ugi reaction with a tandem S(N)2'-Heck double cyclization

J Org Chem. 2010 Aug 6;75(15):5134-43. doi: 10.1021/jo100859y.

Authors

Renata Riva¹, Luca Banfi, Andrea Basso, Valentina Cerulli, Giuseppe Guanti, Marcella Pani

Affiliation

¹ Dipartimento di Chimica e Chimica Industriale, Via Docecaneso 31, 16146 Genova, Italy. riva@chimica.unige.it

PMID: 20575586
DOI: 10.1021/jo100859y

Abstract

A small library of natural product-like compounds has been assembled by coupling an Ugi multicomponent reaction with two postcondensation transformations, carried out in one-pot fashion: a S(N)2' cyclization followed by an intramolecular Heck reaction.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cyclization
Heterocyclic Compounds / chemical synthesis*
Heterocyclic Compounds / chemistry
Magnetic Resonance Spectroscopy
Models, Molecular

Substances

Heterocyclic Compounds