Abstract
Low-frequency fatigue (LFF) is characterized by a proportionally greater loss of force at low compared with high activation frequencies and a prolonged recovery. Recent work suggests a calcium-induced uncoupling of excitation-contraction coupling underlies LFF. Here, newly characterized triadic proteins are described, and possible mechanisms by which they may contribute to LFF are suggested.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Calcium / physiology
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Calcium Channels / physiology
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Excitation Contraction Coupling / physiology*
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Humans
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Membrane Proteins / physiology
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Mice
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Muscle Contraction / physiology
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Muscle Fatigue / physiology*
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Muscle Proteins / physiology*
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Muscle, Skeletal / physiology
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Ryanodine Receptor Calcium Release Channel / physiology*
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Sarcoplasmic Reticulum / physiology
Substances
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Calcium Channels
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Membrane Proteins
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Muscle Proteins
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Ryanodine Receptor Calcium Release Channel
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Calcium