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, 59 (24), 750

Detection of Enterobacteriaceae Isolates Carrying Metallo-Beta-Lactamase - United States, 2010

  • PMID: 20577157

Detection of Enterobacteriaceae Isolates Carrying Metallo-Beta-Lactamase - United States, 2010

Centers for Disease Control and Prevention (CDC). MMWR Morb Mortal Wkly Rep.

Abstract

During January-June 2010, three Enterobacteriaceae isolates carrying a newly described resistance mechanism, the New Delhi metallo-beta-lactamase (NDM-1), were identified from three U.S. states at the CDC antimicrobial susceptibility laboratory. This is the first report of NDM-1 in the United States, and the first report of metallo-beta-lactamase carriage among Enterobacteriaceae in the United States. These isolates, which include an Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae, carry blaNDM-1, which confers resistance to all beta-lactam agents except aztreonam (a monobactam antimicrobial); all three isolates were aztreonam resistant, presumably by a different mechanism. In the United Kingdom, where these organisms are increasingly common, carriage of Enterobacteriaceae containing blaNDM-1 has been closely linked to receipt of medical care in India and Pakistan. All three U.S. isolates were from patients who received recent medical care in India.

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