Neurotoxicity of cancer chemotherapy

Semin Neurol. 2010 Jul;30(3):273-86. doi: 10.1055/s-0030-1255217. Epub 2010 Jun 24.


Neurologic dysfunction is a common side effect of many chemotherapy drugs. For several agents, neurotoxicity is common, severe, and can be dose-limiting. As the list of newer chemotherapy agents and systemic "targeted therapies" grows, so does the number and variety of potential neurotoxicities. This is a review of the clinical features of chemotherapy-induced syndromes involving the central and peripheral nervous systems.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Agents / therapeutic use
  • Brain Diseases / chemically induced*
  • Brain Diseases / complications
  • Brain Diseases / drug therapy
  • Humans
  • Neoplasms / complications
  • Neoplasms / drug therapy
  • Peripheral Nervous System Diseases / chemically induced*
  • Peripheral Nervous System Diseases / complications
  • Peripheral Nervous System Diseases / drug therapy
  • Spinal Cord Diseases / chemically induced*
  • Spinal Cord Diseases / complications
  • Spinal Cord Diseases / drug therapy


  • Antineoplastic Agents