Regulation of the G2/M transition in rodent oocytes

Mol Reprod Dev. 2010 Jul;77(7):566-85. doi: 10.1002/mrd.21175.


Regulation of maturation in meiotically competent mammalian oocytes is a complex process involving the carefully coordinated exchange of signals between the somatic and germ cell compartments of the ovarian follicle via paracrine and cell-cell coupling pathways. This review highlights recent advances in our understanding of how such signaling controls both meiotic arrest and gonadotropin-triggered meiotic resumption in competent oocytes and relates them to the historical context. Emphasis will be on rodent systems, where many of these new findings have taken place. A regulatory scheme is then proposed that integrates this information into an overall framework for meiotic regulation that demonstrates the complex interplay between different follicular compartments.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Division / physiology*
  • G2 Phase / physiology*
  • Oocytes / physiology*
  • Rodentia
  • Signal Transduction / physiology*