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. 2010 Jul;24(7):1104-6.
doi: 10.1002/ptr.3133.

The Development of Artemisinin Resistance in Malaria: Reasons and Solutions

The Development of Artemisinin Resistance in Malaria: Reasons and Solutions

Cosima Chrubasik et al. Phytother Res. .

Abstract

Despite world-wide efforts in fighting malaria, this mosquito-borne infectious disease is a huge burden for the population, especially in tropical and subtropical areas. The WHO recommends artemisinin-based combination therapy for the treatment of uncomplicated Plasmodium falciparum malaria. However, artemisinin resistance cannot now be ignored. Factors affecting the development of artemisinin resistance include uncontrolled use of artemisinin-based combination therapy (ACT), mobile populations and migrants, artemisinin monotherapy, the use of subtherapeutic levels of artesiminin, substandard and counterfeit drugs, high treatment cost, and co-use of artemisinin derivates as prophylactic agents. Promising herbal alternatives are already in the pipeline, but the only long-term solution for eradicating malaria would be the development of a successful vaccination.

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