Intestinal Stem Cell Asymmetric Division in the Drosophila Posterior Midgut

J Cell Physiol. 2010 Sep;224(3):581-4. doi: 10.1002/jcp.22194.

Abstract

Over the past 2 years, our understanding of intestinal stem cells in the Drosophila posterior midgut has advanced greatly. In this review, I will focus on the establishment of these stem cells in their niche during development and the molecular mechanisms that regulate their asymmetric division in adults.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation / physiology
  • Cell Division / physiology*
  • Cell Proliferation
  • Drosophila Proteins / metabolism
  • Drosophila melanogaster / anatomy & histology*
  • Intestines / cytology*
  • Intestines / physiology
  • Janus Kinase 1 / metabolism
  • STAT Transcription Factors / metabolism
  • Signal Transduction / physiology
  • Stem Cells / cytology
  • Stem Cells / physiology*
  • Wnt1 Protein / metabolism

Substances

  • Drosophila Proteins
  • STAT Transcription Factors
  • Wnt1 Protein
  • wg protein, Drosophila
  • Janus Kinase 1