Extensive hypertrophic lichen planus in an HIV positive patient

Dermatol Online J. 2010 Jun 15;16(6):8.

Abstract

Individuals who are infected with Human Immunodeficiency Virus (HIV) suffer from numerous dermatoses. These disorders are often more severe than those observed in non HIV-infected persons afflicted with the same diseases. Lichen planus (LP) is a chronic inflammatory papulosquamous skin disorder. Herein, the diagnosis and treatment of a 40-year-old HIV+ Kenyan man afflicted with hypertrophic lichen planus (HLP) is described. In this case, lesions of HLP were widely distributed across the trunk and extremities, having become of such thickness on the dorsal surfaces of the hands and fingers as to make normal use of hands impossible. A significant distinguishing feature of this patient is prior history of tuberculosis, which is a known trigger for lichenoid skin lesions.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-HIV Agents / therapeutic use
  • Clobetasol / therapeutic use
  • Drug Combinations
  • HIV Infections / complications*
  • Hand Dermatoses / diagnosis
  • Hand Dermatoses / drug therapy
  • Hand Dermatoses / pathology*
  • Humans
  • Lamivudine / therapeutic use
  • Lichen Planus / drug therapy
  • Lichen Planus / etiology
  • Lichen Planus / pathology*
  • Male
  • Nevirapine / therapeutic use
  • Pruritus / drug therapy
  • Stavudine / therapeutic use
  • Treatment Outcome
  • Tuberculosis, Pulmonary / complications

Substances

  • Anti-HIV Agents
  • Drug Combinations
  • stavudine, lamivudine, nevirapine drug combination
  • Lamivudine
  • Nevirapine
  • Clobetasol
  • Stavudine