Idiopathic recurrent pregnancy loss recurs at similar gestational ages

Am J Obstet Gynecol. 2010 Oct;203(4):343.e1-5. doi: 10.1016/j.ajog.2010.05.010. Epub 2010 Jul 1.


Objective: To determine whether a correlation exists between gestational ages of idiopathic recurrent pregnancy loss (iRPL).

Study design: Cohort of women with iRPL who had an initial loss (qualifying pregnancy [QP]) with precise documentation of gestational age. Outcomes in the immediate next pregnancy (index pregnancy [IP]) were compared between preembryonic (group I), embryonic (group II), or fetal (group III) losses in the QP.

Results: Three hundred thirty-four women met inclusion criteria. In their IP, group I had 41% preembryonic, 28% embryonic, and 10% fetal losses. Group II had 14% preembryonic, 53% embryonic, and 9% fetal losses. Group III had 19% preembryonic, 23% embroyonic, and 29% fetal loses. Correlation coefficient for type of loss among the QPs and IPs was 0.14, P = .009.

Conclusions: Women with iRPL tend to have losses recur in the same gestational age period. Causes for RPL may be gestational age specific and should guide further investigations into causes.

MeSH terms

  • Abortion, Habitual / epidemiology*
  • Adult
  • Cohort Studies
  • Female
  • Gestational Age*
  • Humans
  • Pregnancy