Pregnancy outcome after in utero exposure to colchicine

Am J Obstet Gynecol. 2010 Aug;203(2):144.e1-6. doi: 10.1016/j.ajog.2010.02.063. Epub 2010 Jul 1.

Abstract

Objective: We sought to examine the fetal safety of colchicine.

Study design: This was a prospective observational comparative cohort study regarding colchicine exposure during pregnancy including contacts to 2 Teratology Information Services in Israel from 1994 through 2006.

Results: In all, 238 colchicine-exposed pregnancies (97.0% first trimester) and 964 pregnancies with nonteratogenic exposure were followed up. Treatment indications were: familial Mediterranean fever (87.3%), Behçet disease (7.5%), or other (5.2%). The rate of major congenital anomalies was comparable between the groups (10/221 [4.5%] vs 35/908 [3.9%]; P = .648). There were no cytogenetic anomalies in the colchicine group. The median gestational age at delivery was earlier (39 [38-40] vs 40 [38-41] weeks; P < .001), the rate of preterm deliveries was higher (32/214 [15.0%] vs 51/867 [5.9%]; P < .001), and the median birthweight was lower (3000 [2688-3300] vs 3300 [2900-3600] g; P < .001) in the colchicine group.

Conclusion: The present study suggests that colchicine does not appear to be a major human teratogen, and, probably, has no cytogenetic effect.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abnormalities, Drug-Induced / diagnosis*
  • Abnormalities, Drug-Induced / epidemiology*
  • Adult
  • Behcet Syndrome / drug therapy
  • Birth Weight
  • Cohort Studies
  • Colchicine / adverse effects*
  • Colchicine / therapeutic use
  • Drug-Related Side Effects and Adverse Reactions
  • Familial Mediterranean Fever / diagnosis
  • Familial Mediterranean Fever / drug therapy
  • Female
  • Fetus / drug effects*
  • Follow-Up Studies
  • Humans
  • Israel
  • Maternal Exposure / adverse effects*
  • Maternal-Fetal Exchange / drug effects
  • Obstetric Labor, Premature
  • Pregnancy
  • Pregnancy Outcome*
  • Pregnancy Trimester, First
  • Prenatal Exposure Delayed Effects / chemically induced*
  • Probability
  • Prospective Studies
  • Risk Assessment
  • Statistics, Nonparametric
  • Teratogens

Substances

  • Teratogens
  • Colchicine