Nuclear gadgets in mitochondrial DNA replication and transcription

Trends Biochem Sci. 1991 Mar;16(3):107-11. doi: 10.1016/0968-0004(91)90043-u.


In mammalian mitochondrial DNA, activation of the light-strand promoter mediates both priming of leading-strand replication and initiation of light-strand transcription. Accurate and efficient transcription requires at least two proteins: mitochondrial RNA polymerase and a separable transcription factor that can function across species boundaries. Subsequently, primer RNAs are cleaved by a site-specific ribonucleoprotein endoribonuclease that recognizes short, highly conserved sequence elements in the RNA substrate.

Publication types

  • Review

MeSH terms

  • Animals
  • DNA Replication*
  • DNA, Mitochondrial / genetics*
  • DNA-Directed RNA Polymerases / metabolism
  • Humans
  • Transcription Factors / metabolism
  • Transcription, Genetic


  • DNA, Mitochondrial
  • Transcription Factors
  • DNA-Directed RNA Polymerases