New Withanolides From Mandragora Officinarum: First Report of Withanolides From the Genus Mandragora

Fitoterapia. 2010 Oct;81(7):864-8. doi: 10.1016/j.fitote.2010.05.013. Epub 2010 May 23.


Two new withanolides named mandragorolide A (1) and mandragorolide B (2) were isolated from the MeOH extract of the whole plant of Mandragora officinarum of Jordanian origin, along with five known withanolides namely larnaxolide A (3), withanolide B (4), datura lactone 2 (5), withanicandrin (6) and salpichrolide C (7). Compound 3 has been reported only once before, from the leaves of Larnax glabra. This is the first report of withanolides of different biogenetic types from the genus Mandragora. Isolation of known fatty compounds, coumarins, sterols and tropane alkaloids was also achieved in this study.

MeSH terms

  • Jordan
  • Mandragora / chemistry*
  • Molecular Structure
  • Plant Extracts / chemistry*
  • Plant Extracts / isolation & purification
  • Withanolides / chemistry
  • Withanolides / isolation & purification*


  • Plant Extracts
  • Withanolides
  • mandragorolide A
  • mandragorolide B