Efficacy of a tin/fluoride Rinse: A Randomized in Situ Trial on Erosion

J Dent Res. 2010 Nov;89(11):1214-8. doi: 10.1177/0022034510375291. Epub 2010 Jun 25.

Abstract

Concentrated tin- and fluoride-containing mouthrinses are effective erosion inhibitors in enamel and dentin. To test whether this is also true for solutions with lower concentrations, we conducted a randomized double-blind three-cell crossover in situ study with extra-orally performed erosive impacts (citric acid, 6 x 5 min/day) and an intra-oral rinsing protocol (1 x 30 sec/day) in 24 volunteers. The mouthrinses were a placebo, a NaF (500 ppm F⁻), and an amine fluoride (AmF)/NaF/SnCl₂ mouthrinse (500 ppm F⁻, 800 ppm Sn(2+)). Compared with the placebo, the NaF mouthrinse reduced substance loss by 19% in enamel and 23% in dentin (p ≤ 0.01 each); the AmF/NaF/SnCl₂ mouthrinse reduced this parameter by 67% in enamel and 47% in dentin (p ≤ 0.001 each). AmF/NaF/SnCl₂ was significantly more effective than NaF in both tissues (p ≤ 0.01). The mouthrinse containing Sn and F exhibited good efficacy, even under severe erosive conditions.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amines / therapeutic use
  • Cariostatic Agents / therapeutic use*
  • Citric Acid / adverse effects
  • Cross-Over Studies
  • Dental Enamel / drug effects
  • Dentin / drug effects
  • Double-Blind Method
  • Female
  • Humans
  • Hydrogen-Ion Concentration
  • Male
  • Mouthwashes / therapeutic use*
  • Placebos
  • Prospective Studies
  • Sodium Fluoride / therapeutic use*
  • Tin Compounds / therapeutic use*
  • Tooth Demineralization / prevention & control
  • Tooth Erosion / prevention & control*
  • Treatment Outcome

Substances

  • Amines
  • Cariostatic Agents
  • Mouthwashes
  • Placebos
  • Tin Compounds
  • stannous chloride
  • Citric Acid
  • Sodium Fluoride