On beyond GWAS

Nat Genet. 2010 Jul;42(7):551. doi: 10.1038/ng0710-551.

Abstract

Analyses of genome-wide association studies (GWAS) show that common SNPs can account for the majority of the heritability of complex traits, but that there are likely to be limits to the usefulness of the current strategy of accumulating common variants of small effect for risk prediction. The ongoing success of GWAS has implications for functional characterization of trait-associated loci.

Publication types

  • Editorial

MeSH terms

  • Genetic Predisposition to Disease / genetics*
  • Genome, Human
  • Genome-Wide Association Study / methods*
  • Genotype
  • Humans
  • Phenotype
  • Polymorphism, Single Nucleotide*