Abstract
Sequence conservation of noncoding DNA across species can indicate functional conservation. However, a new study demonstrates notable differences between human and mouse stem cell regulatory networks, suggesting caution in generalizing from sequence to functional conservation.
MeSH terms
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Animals
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Binding Sites / genetics
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CCCTC-Binding Factor
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DNA Transposable Elements / genetics*
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Embryonic Stem Cells / metabolism*
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Gene Regulatory Networks*
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Genome-Wide Association Study
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Homeodomain Proteins / genetics
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Homeodomain Proteins / metabolism
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Humans
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Mice
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Models, Genetic
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Nanog Homeobox Protein
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Octamer Transcription Factor-3 / genetics
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Octamer Transcription Factor-3 / metabolism
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Protein Binding
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Regulatory Sequences, Nucleic Acid / genetics*
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Repressor Proteins / genetics
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Repressor Proteins / metabolism
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Species Specificity
Substances
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CCCTC-Binding Factor
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CTCF protein, human
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Ctcf protein, mouse
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DNA Transposable Elements
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Homeodomain Proteins
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NANOG protein, human
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Nanog Homeobox Protein
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Nanog protein, mouse
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Octamer Transcription Factor-3
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POU5F1 protein, human
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Pou5f1 protein, mouse
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Repressor Proteins