Limits of sequence and functional conservation

Nat Genet. 2010 Jul;42(7):557-8. doi: 10.1038/ng0710-557.

Abstract

Sequence conservation of noncoding DNA across species can indicate functional conservation. However, a new study demonstrates notable differences between human and mouse stem cell regulatory networks, suggesting caution in generalizing from sequence to functional conservation.

Publication types

  • News

MeSH terms

  • Animals
  • Binding Sites / genetics
  • CCCTC-Binding Factor
  • DNA Transposable Elements / genetics*
  • Embryonic Stem Cells / metabolism*
  • Gene Regulatory Networks*
  • Genome-Wide Association Study
  • Homeodomain Proteins / genetics
  • Homeodomain Proteins / metabolism
  • Humans
  • Mice
  • Models, Genetic
  • Nanog Homeobox Protein
  • Octamer Transcription Factor-3 / genetics
  • Octamer Transcription Factor-3 / metabolism
  • Protein Binding
  • Regulatory Sequences, Nucleic Acid / genetics*
  • Repressor Proteins / genetics
  • Repressor Proteins / metabolism
  • Species Specificity

Substances

  • CCCTC-Binding Factor
  • CTCF protein, human
  • Ctcf protein, mouse
  • DNA Transposable Elements
  • Homeodomain Proteins
  • NANOG protein, human
  • Nanog Homeobox Protein
  • Nanog protein, mouse
  • Octamer Transcription Factor-3
  • POU5F1 protein, human
  • Pou5f1 protein, mouse
  • Repressor Proteins