Hints of hidden heritability in GWAS

Nat Genet. 2010 Jul;42(7):558-60. doi: 10.1038/ng0710-558.


Although susceptibility loci identified through genome-wide association studies (GWAS) typically explain only a small proportion of the heritability, a classical quantitative genetic analysis now argues that considering together all common SNPs can explain a large proportion of the heritability of these complex traits. A related study provides recommendations for the sample sizes needed in future GWAS to identify additional susceptibility loci.

Publication types

  • News

MeSH terms

  • Body Height / genetics
  • Breast Neoplasms / genetics
  • Colorectal Neoplasms / genetics
  • Crohn Disease / genetics
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease / genetics*
  • Genome-Wide Association Study / methods*
  • Genotype
  • Humans
  • Male
  • Polymorphism, Single Nucleotide*
  • Prostatic Neoplasms / genetics