Current Enoxaparin Dosing Guidelines Have Dubious Credibility

N Z Med J. 2010 Apr 30;123(1313):62-7.

Abstract

Aim: To assess the prescribing practice of enoxaparin in comparison to dosing guidelines.

Method: A prospective observational chart review of patients who received enoxaparin for the treatment of thrombosis at Dunedin Public Hospital between August 2007 and January 2008. Deviations in dose from guidelines were defined and recorded along with various clinical and demographic data of participants.

Results: Fifty-nine patients (62 admissions) were recruited. Dose deviations occurred on 19 (30.7%) occasions. More dose deviations occurred at or close to guideline transition points (total body weight over 90 kg and/or creatinine clearance between 20-40 mL/min).

Conclusion: Current enoxaparin dosing guidelines are too simplistic and result in discord between dosing in practice and that approved by Medsafe.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anticoagulants / administration & dosage
  • Drug Prescriptions / standards*
  • Enoxaparin / administration & dosage*
  • Humans
  • Practice Guidelines as Topic*
  • Thrombosis / drug therapy*

Substances

  • Anticoagulants
  • Enoxaparin