Abstract
A bis-guanylhydrazone derivative of diimidazo[1,2-a:1,2-c]pyrimidine has unexpectedly been found to be a potent stabiliser of several quadruplex DNAs, whereas there is no significant interaction with duplex DNA. Molecular modeling suggests that the guanylhydrazone groups play an active role in quadruplex binding.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Computer Simulation
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DNA / chemistry
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Fluorescence Resonance Energy Transfer
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G-Quadruplexes*
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Mitoguazone / analogs & derivatives*
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Mitoguazone / chemistry
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Models, Molecular
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Pyrimidines / chemistry*
Substances
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Pyrimidines
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bis-guanylhydrazone diimidazo(1,2-a-1,2-c)pyrimidine
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DNA
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Mitoguazone