Joining the interface: a site for Nmd3 association on 60S ribosome subunits

J Cell Biol. 2010 Jun 28;189(7):1071-3. doi: 10.1083/jcb.201006033.


The adaptor protein Nmd3 is required for Crm1-dependent export of large ribosomal subunits from the nucleus. In this issue, Sengupta et al. (2010. J. Cell Biol. doi:10.1083/jcb.201001124) identify a binding site for yeast Nmd3 on 60S ribosomal subunits using cryoelectron microscopy and suggest a conformational model for its release in the cytoplasm. The study provides the first detailed structural description of a ribosome biogenesis factor in complex with the large subunit.

Publication types

  • Comment
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Binding Sites
  • Cell Nucleus
  • Cryoelectron Microscopy
  • Fungal Proteins / metabolism
  • RNA-Binding Proteins / metabolism*
  • Ribosome Subunits, Large, Eukaryotic / metabolism*
  • Saccharomyces cerevisiae Proteins / metabolism*


  • Fungal Proteins
  • NMD3 protein, S cerevisiae
  • RNA-Binding Proteins
  • Saccharomyces cerevisiae Proteins