Comparative study of cerebellar degeneration in canine neuroaxonal dystrophy, cerebellar cortical abiotrophy, and neuronal ceroid-lipofuscinosis

J Vet Med Sci. 2010 Nov;72(11):1495-9. doi: 10.1292/jvms.10-0072. Epub 2010 Jun 24.

Abstract

The cerebellar lesions of three dogs with canine neuroaxonal dystrophy (NAD), one dog with cerebellar cortical abiotrophy (CCA), and 4 dogs with neuronal ceroid-lipofuscinosis (NCL) were examined to understand their pathogeneses. Purkinje cell loss was most severe in the vermis of a dog with CCA, and granule cell loss was most prominent in the cerebellar hemisphere of dogs with NCL. Immunohistochemically, CD3-and HLA-DR-positive cells were most frequent in the dogs with NCL, and moderate in dogs with NAD, but not in a dog with CCA. The number of cleaved caspase 3-positive cells was prominent in a dog with CCA, but no significant in the dogs with NAD. The results indicate different pathway of neuronal loss of these canine neuronal disorders.

MeSH terms

  • Animals
  • Caspase 3 / metabolism
  • Cerebellar Cortex / enzymology
  • Cerebellar Cortex / pathology
  • Cerebellum / pathology
  • Dog Diseases / pathology*
  • Dogs
  • Female
  • Male
  • Neuroaxonal Dystrophies / enzymology
  • Neuroaxonal Dystrophies / mortality
  • Neuroaxonal Dystrophies / pathology
  • Neuroaxonal Dystrophies / veterinary*
  • Neuronal Ceroid-Lipofuscinoses / mortality
  • Neuronal Ceroid-Lipofuscinoses / pathology
  • Neuronal Ceroid-Lipofuscinoses / veterinary*
  • Orchiectomy / veterinary
  • Purkinje Cells / pathology
  • Spinocerebellar Degenerations / pathology
  • Spinocerebellar Degenerations / veterinary*

Substances

  • Caspase 3