Comparative genome analysis of Prevotella ruminicola and Prevotella bryantii: insights into their environmental niche

Microb Ecol. 2010 Nov;60(4):721-9. doi: 10.1007/s00248-010-9692-8. Epub 2010 Jun 29.


The Prevotellas comprise a diverse group of bacteria that has received surprisingly limited attention at the whole genome-sequencing level. In this communication, we present the comparative analysis of the genomes of Prevotella ruminicola 23 (GenBank: CP002006) and Prevotella bryantii B(1)4 (GenBank: ADWO00000000), two gastrointestinal isolates. Both P. ruminicola and P. bryantii have acquired an extensive repertoire of glycoside hydrolases that are targeted towards non-cellulosic polysaccharides, especially GH43 bifunctional enzymes. Our analysis demonstrates the diversity of this genus. The results from these analyses highlight their role in the gastrointestinal tract, and provide a template for additional work on genetic characterization of these species.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Genome, Bacterial*
  • Molecular Sequence Data
  • Phylogeny
  • Prevotella / classification
  • Prevotella / enzymology
  • Prevotella / genetics*
  • Prevotella / isolation & purification
  • Prevotella ruminicola / classification
  • Prevotella ruminicola / enzymology
  • Prevotella ruminicola / genetics*
  • Prevotella ruminicola / isolation & purification
  • Rumen / microbiology


  • Bacterial Proteins