Geographic differences in genetic locus linkages for Borrelia burgdorferi

Emerg Infect Dis. 2010 Jul;16(7):1147-50. doi: 10.3201/eid1607.091452.


Borrelia burdorferi genotype in the northeastern United States is associated with Lyme borreliosis severity. Analysis of DNA sequences of the outer surface protein C gene and rrs-rrlA intergenic spacer from extracts of Ixodes spp. ticks in 3 US regions showed linkage disequilibrium between the 2 loci within a region but not consistently between regions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antigens, Bacterial / genetics
  • Bacterial Outer Membrane Proteins / genetics
  • Borrelia burgdorferi / genetics*
  • Genetic Linkage*
  • Genetic Loci*
  • Ixodes / microbiology
  • New England


  • Antigens, Bacterial
  • Bacterial Outer Membrane Proteins
  • OspC protein