Effect of 1,6-hexamethylene diisocyanate exposure on peak flowmetry in automobile paint shop workers in Iran

Arh Hig Rada Toksikol. 2010 Jun;61(2):183-9. doi: 10.2478/10004-1254-61-2010-1994.


The aim of this study was to investigate the effects of occupational exposure to 1,6-hexamethylene diisocyanate (HDI) on peak flowmetry in automobile body paint shop workers in Iran. We studied a population of 43 car painters exposed to HDI at their workplaces. Peak expiratory flow was tested for one working week, from the start to the end of each shift. Air was sampled and HDI analysed in parallel, according to the OSHA 42 method. Daily and weekly HDI exposure averages were (0.42+/-0.1) mg m(-3) and (0.13+/-0.05) mg m(-3), respectively. On painting days, 72 % of workers showed more than a 10 % variation in peak expiratory flow. Inhalation exposure exceeded the threshold limit value (TLV) ten times over. This strongly suggests that HDI affected the peak flowmetry in the studied workers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Air Pollutants, Occupational / adverse effects*
  • Chromatography, High Pressure Liquid
  • Cyanates / adverse effects*
  • Humans
  • Isocyanates
  • Male
  • Middle Aged
  • Occupational Exposure*
  • Paint*
  • Peak Expiratory Flow Rate*
  • Young Adult


  • Air Pollutants, Occupational
  • Cyanates
  • Isocyanates
  • 1,6-hexamethylene diisocyanate