NF1 inactivation revs up Ras in adult acute myelogenous leukemia

Clin Cancer Res. 2010 Aug 15;16(16):4074-6. doi: 10.1158/1078-0432.CCR-10-1438. Epub 2010 Jun 29.


Mutations in the Ras pathway are common in myeloid malignancies. NF1, a tumor suppressor and negative regulator of Ras, is inactivated in a subset of adult acute myelogenous leukemia (AML) cases. Loss of NF1 function sensitizes cells to inhibition of mammalian target of rapamycin (mTOR), a downstream effector of Ras activation, highlighting a potential therapeutic opportunity for some AML patients.

Publication types

  • Review

MeSH terms

  • Adult
  • Gene Expression
  • Gene Expression Regulation, Neoplastic / genetics*
  • Gene Silencing
  • Genes, Neurofibromatosis 1*
  • Humans
  • Leukemia, Myeloid, Acute / genetics*
  • Signal Transduction / genetics*
  • ras Proteins / biosynthesis*


  • ras Proteins