Design and methodologies of the POSTconditioning during coronary angioplasty in acute myocardial infarction (POST-AMI) trial

Cardiology. 2010;116(2):110-6. doi: 10.1159/000316967. Epub 2010 Jun 29.


Background: Reperfusion remains the definitive treatment for acute myocardial infarction (AMI), but restoring blood flow carries the potential to exacerbate the ischemia-related injury. Postconditioning might modify reperfusion-induced adverse events.

Study design: The POSTconditioning during Coronary Angioplasty in Acute Myocardial Infarction (POST-AMI) trial is a single-center, prospective, randomized study, with a planned inclusion of 78 patients with ST-elevation AMI. Patients will be randomly assigned to the postconditioning arm [primary angioplasty (PA) and stenting followed by brief episodes of ischemia-reperfusion early after recanalization] or non-postconditioning arm. All patients will be treated medically according to current international guidelines, including glycoprotein IIb/IIIa inhibitors before PA. The primary end point is to evaluate whether postconditioning, compared to plain PA, reduces infarct size estimated by cardiac magnetic resonance (CMR) at 30 +/- 10 days after the AMI. Secondary end points are microvascular obstruction observed at CMR, ST-segment resolution, angiographic myocardial blush grade <2, non-sustained/sustained ventricular tachycardia in the 48 h following PA, left ventricular remodeling and function at follow-up CMR, and the reduction of major adverse cardiac events at 30 days and 6 months.

Conclusion: The POST-AMI trial will evaluate the usefulness of postconditioning in limiting infarct size during the early and late phases after AMI.

Trial registration: NCT01004289.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Angioplasty, Balloon, Coronary / methods*
  • Female
  • Follow-Up Studies
  • Humans
  • Ischemic Preconditioning, Myocardial / methods*
  • Magnetic Resonance Imaging
  • Male
  • Myocardial Infarction / pathology
  • Myocardial Infarction / therapy*
  • Myocardial Ischemia / pathology
  • Myocardial Ischemia / therapy*
  • Prognosis
  • Research Design

Associated data