Asymptomatic colonization of upper respiratory tract by potential bacterial pathogens

Indian J Pediatr. 2010 Jul;77(7):775-8. doi: 10.1007/s12098-010-0118-x. Epub 2010 Jun 29.


Objective: To screen for asymptomatic respiratory carriage of S. pneumoniae, H. influenzae and Group A Streptococcus (GAS) in children attending JIPMER, correlate carriage rate with different socio-demographic factors and to detect antimicrobial resistance among the isolates.

Methods: Throat swabs were collected from both in patients and out patients (<or=12 yr of age) and processed. Bacteria were identified by Standard techniques. Susceptibility to commonly used antimicrobial agents was determined by Kirby Bauer disc diffusion technique.

Results: Overall carriage rate of respiratory pathogens was 30% with S. pneumoniae, H. influenzae and GAS accounting for 22%, 5% and 4.5% respectively. Three patients had >1 organism. Antibiotic resistance was highest in S. pneumoniae with 66.7% of strains resistant to penicillin. MDR strains were also encountered. Erythromycin resistance was observed in both H. influenzae (28.4%) and GAS (22%). No statistically significant association was found between the carriage rate of these organisms and different socio-demographic factors.

Conclusions: S. pneumoniae carriage rate was comparatively higher in the Community and its antimicrobial resistance is an issue to address.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Distribution
  • Carrier State / epidemiology*
  • Carrier State / microbiology
  • Carrier State / prevention & control
  • Child
  • Child, Preschool
  • Drug Resistance, Bacterial*
  • Female
  • Haemophilus influenzae* / drug effects
  • Humans
  • India / epidemiology
  • Infant
  • Infant, Newborn
  • Male
  • Mass Screening
  • Respiratory Tract Infections / epidemiology*
  • Respiratory Tract Infections / microbiology
  • Respiratory Tract Infections / prevention & control
  • Risk Factors
  • Socioeconomic Factors
  • Streptococcus pneumoniae* / drug effects
  • Streptococcus pyogenes* / drug effects