Neuromodulation of decision-making in the addictive brain

Subst Use Misuse. 2010 Sep;45(11):1766-86. doi: 10.3109/10826084.2010.482434.


Noninvasive brain stimulation of the dorsolateral prefrontal cortex with repetitive transcranial magnetic stimulation and transcranial direct current stimulation can modify decision-making behaviors in healthy subjects. The same type of noninvasive brain stimulation can suppress drug craving in substance user patients, who often display impaired decision-making behaviors. We discuss the implications of these studies for the cognitive neurosciences and their translational applications to the treatment of addictions. We propose a neurocognitive model that can account for our findings and suggests a promising therapeutic role of brain stimulation in the treatment of substance abuse and addictive behavior disorders.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Behavior, Addictive / psychology*
  • Brain / physiology*
  • Decision Making*
  • Humans
  • Models, Biological
  • Neurotransmitter Agents*
  • Transcranial Magnetic Stimulation


  • Neurotransmitter Agents