Treatment of De Quervain's tenosynovitis with corticosteroids. A prospective study of the response to local injection

Arthritis Rheum. 1991 Jul;34(7):793-8. doi: 10.1002/art.1780340703.


Fifty-six cases of De Quervain's tenosynovitis (in 55 patients) were treated with a "long-acting" corticosteroid, methylprednisolone acetate, and followed prospectively over a 4-year period. Approximately 90% of these patients were effectively managed either with a single injection (58%) or with multiple injections (33%) of this compound. Seventeen patients experienced recurrence a mean of 11.9 months after the initial injection. Three had minor flares and were not reinjected; the others responded to reinjections. Ten percent of the cases could not be controlled with local injection, and these patients were referred for surgery. Adverse reactions were self-limited and relatively minor; no tendon ruptures or local infections occurred. We present a discussion of our review of the literature regarding medical therapy and surgical release for this condition. Treatment of De Quervain's tenosynovitis with methylprednisolone acetate injection rapidly controls the signs and symptoms, does not lead to serious adverse reactions, and should be the preferred initial treatment.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Inflammatory Agents / administration & dosage*
  • Anti-Inflammatory Agents / adverse effects
  • Anti-Inflammatory Agents / therapeutic use
  • Delayed-Action Preparations
  • Drug Evaluation
  • Female
  • Follow-Up Studies
  • Humans
  • Injections / adverse effects
  • Injections / methods
  • Male
  • Methylprednisolone / administration & dosage
  • Methylprednisolone / adverse effects
  • Methylprednisolone / analogs & derivatives*
  • Methylprednisolone / therapeutic use
  • Methylprednisolone Acetate
  • Middle Aged
  • Prospective Studies
  • Remission Induction
  • Rupture
  • Tendon Injuries / etiology
  • Tendons
  • Tenosynovitis / drug therapy*


  • Anti-Inflammatory Agents
  • Delayed-Action Preparations
  • Methylprednisolone Acetate
  • Methylprednisolone