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. 2010 Aug;32(4):497-503.
doi: 10.1097/FTD.0b013e3181e44293.

Excretion of Methadone in Sweat of Pregnant Women Throughout Gestation After Controlled Methadone Administration

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Free PMC article

Excretion of Methadone in Sweat of Pregnant Women Throughout Gestation After Controlled Methadone Administration

Allan J Barnes et al. Ther Drug Monit. .
Free PMC article

Abstract

Sweat patches (n = 350) were collected throughout gestation from 29 opioid-dependent pregnant women participating in an outpatient methadone-assisted therapy program. Volunteers provided informed consent to participate in institutional review board-approved protocols. Methadone was eluted from sweat patches with sodium acetate buffer, followed by solid-phase extraction and quantification by gas chromatography mass spectrometry (limit of quantification > or = 10 ng/patch). Methadone was present in all weekly patches (n = 311) in concentrations ranging from 10.2 to 12,129.7 nanograms per patch and in 92.3% of short-term patches (n = 39, worn for 12 or 24 hours) in concentrations up to 3303.9 nanograms per patch. Correlation between patch concentrations and total amount of drug administered (r = 0.224), and concentrations and duration of patch wear (r = 0.129) were both weak. Although there were large intra- and intersubject variations in sweat drug concentrations, sweat testing was an effective alternative technique to qualitatively monitor illicit drug use and simultaneously document methadone medication-assisted treatment.

Figures

Figure 1
Figure 1
Time course of methadone excretion in sweat patches worn for different durations (3–12 days) and following identical daily methadone doses (60, 70 or 80 mg)
Figure 2
Figure 2
Excretion profiles of weekly patch concentrations (ng/patch) and weekly methadone dose (mg) from 3 representative subjects.

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