Abstract
Six new oxygenated daphnane-type diterpenoids, trigoxyphins A-F (1-6), a phenanthrene-type diterpenoid, trigoxyphin G (7), and two known compounds were isolated from twigs of Trigonostemon xyphophylloides. Their structures were established using spectroscopic methods. Compounds 1 and 2 exhibited strong cytotoxic activity against HL60 (IC(50): 0.27 and 0.49 microM) and A549 (IC(50): 7.5 and 4.9 microM) tumor cell lines, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Euphorbiaceae / chemistry*
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HL-60 Cells
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Humans
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Phenanthrenes / chemistry
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Phenanthrenes / isolation & purification*
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Phenanthrenes / pharmacology
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Plant Stems / chemistry
Substances
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Diterpenes
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Drugs, Chinese Herbal
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Phenanthrenes
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trigoxyphin A
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trigoxyphin B
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trigoxyphin G
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mezerein