Experimental encephalomyocarditis virus infection in small laboratory rodents

J Comp Pathol. 2011 Jan;144(1):25-40. doi: 10.1016/j.jcpa.2010.05.001. Epub 2010 Jul 1.

Abstract

Encephalomyocarditis virus (EMCV) is a cardiovirus that belongs to the family Picornaviridae. EMCV is an important cause of acute myocarditis in piglets and of fetal death or abortion in pregnant sows. Small rodents, especially rats, have been suspected to be reservoir hosts or carriers. This virus also induces type 1 diabetes mellitus, encephalomyelitis, myocarditis, orchitis and/or sialodacryoadenitis in small laboratory rodents. This paper reviews the pathology and pathogenesis of experimental infection with EMCV in small laboratory rodents.

Publication types

  • Review

MeSH terms

  • Animals
  • Brain / pathology
  • Brain / virology
  • Cardiovirus Infections / pathology*
  • Cardiovirus Infections / virology
  • Cricetinae
  • Diabetes Mellitus / pathology
  • Diabetes Mellitus / virology
  • Disease Models, Animal
  • Disease Reservoirs / virology
  • Encephalomyelitis / pathology
  • Encephalomyelitis / virology
  • Encephalomyocarditis virus / physiology*
  • Gerbillinae
  • Guinea Pigs
  • Humans
  • Male
  • Mesocricetus
  • Mice
  • Myocarditis / pathology
  • Myocarditis / virology
  • Orchitis / pathology
  • Orchitis / virology
  • Rats
  • Sialadenitis / pathology
  • Sialadenitis / virology