Host response to influenza virus: protection versus immunopathology

Curr Opin Immunol. 2010 Aug;22(4):475-81. doi: 10.1016/j.coi.2010.06.003. Epub 2010 Jun 30.


Host responses play crucial roles in defense against influenza but sometimes these may contribute to immunopathology. Potentially, this may be more important in disease caused by viruses such as avian influenza A H5N1 or the 1918 H1N1 influenza virus rather than with seasonal influenza or pandemic H1N1 2009 (pdmH1N1). Understanding pathogenesis will help develop novel therapeutic options that minimize immunopathology without impairing beneficial host defenses.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptive Immunity
  • Animals
  • Birds
  • CD4-Positive T-Lymphocytes / immunology
  • CD8-Positive T-Lymphocytes / immunology
  • Humans
  • Immunity, Innate / physiology*
  • Influenza A Virus, H1N1 Subtype / immunology*
  • Influenza A Virus, H5N1 Subtype / immunology*
  • Influenza in Birds / immunology
  • Influenza in Birds / prevention & control*
  • Influenza, Human / immunology
  • Influenza, Human / prevention & control*