Diagrammatic representation of the distribution of DNA bases and its applications

Int J Biol Macromol. 1991 Feb;13(1):45-9. doi: 10.1016/0141-8130(91)90009-j.

Abstract

The frequencies of occurrence of the bases A, C, G and T (or U) in a DNA or mRNA sequence are denoted by a, c, g, t (or u), respectively. Since a + c + g + t = 1, the four real numbers are mapped into a point within a regular tetrahedron. The mapping points are then projected to some planes for further study. We have given several examples of application of this technique. As a by-product of an application we have found an empirical formula on the limit distribution of DNA bases for different kind of organisms, i.e. 1/4 less than or equal to a2 + c2 + g2 + t2 less than 1/3.

MeSH terms

  • Adenine / analysis
  • Animals
  • Bacteria / genetics
  • Base Composition*
  • Biological Evolution
  • Codon
  • Cytosine / analysis
  • DNA / chemistry*
  • Genetic Variation / genetics
  • Guanine / analysis
  • Humans
  • Linear Models
  • Mathematics
  • Plants / genetics
  • RNA, Messenger / chemistry
  • Thymine / analysis
  • Uracil / analysis

Substances

  • Codon
  • RNA, Messenger
  • Uracil
  • Guanine
  • Cytosine
  • DNA
  • Adenine
  • Thymine