Exposure error masks the relationship between traffic-related air pollution and heart rate variability

J Occup Environ Med. 2010 Jul;52(7):685-92. doi: 10.1097/JOM.0b013e3181e8071f.

Abstract

Objective: We examined whether more precise exposure measures would better detect associations between traffic-related pollution, elemental carbon (EC), nitrogen dioxide (NO2), and heart rate variability (HRV).

Methods: Repeated 24-hour personal and ambient PM2.5, EC, and NO2 were measured for 30 people living in Atlanta, GA. The association between HRV and either ambient concentrations or personal exposures was examined using linear mixed effects models.

Results: Ambient PM2.5, EC, NO2, and personal PM2.5 were not associated with HRV. Personal EC and NO2 measured 24 hours before HRV were associated with decreased RMSSD, PNN50, and HF and with increased LF/HF. RMSSD decreased by 10.97% (95% confidence interval: -18.00 to -3.34) for an inter-quartile range change in personal EC (0.81 microg/m3).

Conclusions: Results indicate decreased vagal tone in response to traffic pollutants, which can best be detected with precise personal exposure measures.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Air Pollution / adverse effects
  • Air Pollution / analysis*
  • Carbon / adverse effects
  • Carbon / analysis
  • Environmental Exposure / adverse effects
  • Environmental Exposure / analysis*
  • Female
  • Georgia
  • Heart Rate / drug effects*
  • Humans
  • Male
  • Myocardial Infarction / chemically induced
  • Myocardial Infarction / physiopathology
  • Nitrogen Dioxide / adverse effects
  • Nitrogen Dioxide / analysis
  • Ozone / adverse effects
  • Ozone / analysis
  • Particle Size
  • Particulate Matter / analysis
  • Particulate Matter / toxicity
  • Pulmonary Disease, Chronic Obstructive / physiopathology
  • Sulfates / adverse effects
  • Sulfates / analysis
  • Vagus Nerve / drug effects*
  • Vagus Nerve / physiopathology
  • Vehicle Emissions / analysis*
  • Vehicle Emissions / toxicity

Substances

  • Particulate Matter
  • Sulfates
  • Vehicle Emissions
  • Ozone
  • Carbon
  • Nitrogen Dioxide