Rab6 and myosin II at the cutting edge of membrane fission

Nat Cell Biol. 2010 Jul;12(7):635-8. doi: 10.1038/ncb0710-635.


Rab GTPases regulate the dynamics of transport carriers by participating in their translocation across the cytoplasm, and in their docking and fusion with acceptor compartments. An interaction between Golgi-associated Rab6 and myosin II has now been shown to regulate the fission of Rab6-positive carriers, illuminating a previously unappreciated role for Rab6 and the actomyosin system in carrier biogenesis.

Publication types

  • News
  • Comment

MeSH terms

  • Actins / metabolism
  • Actomyosin / metabolism*
  • Biological Transport / physiology
  • Golgi Apparatus / metabolism*
  • HeLa Cells
  • Humans
  • Intracellular Membranes / metabolism*
  • Models, Biological
  • Myosin Type II / metabolism*
  • Signal Transduction / physiology
  • rab GTP-Binding Proteins / metabolism*


  • Actins
  • Rab6 protein
  • Actomyosin
  • Myosin Type II
  • rab GTP-Binding Proteins