[Immune-regulating effect of phenibut under lipopolysaccharide-induced immune stress conditions]

Eksp Klin Farmakol. 2010 May;73(5):30-2.
[Article in Russian]


The immunoregulating effect of phenibut has been demonstrated on the model of immune stress caused by the injection of lipopolysaccharide from Pseudomonas aeruginosa. The degree of expression of the specific (in a delayed-type hypersensitivity reaction and passive hemagglutination) and nonspecific (phagocytic activity of neutrophils) links of immunomodulation was studied. The formation of lipopolysaccharide (LPS) induced immune stress is characterized by the increase of the indicated parameters of immunity. It is found that phenibut (under intraabdominal injection of 25 mg/kg within 5 days) removes the manifestations of hyperreactivity of the cellular link of immunity, and also restores the amount of phagocytic cells, which is evidence of the immunomodulating properties of the drug under conditions of hyperimmunization.

MeSH terms

  • Animals
  • Female
  • Hemagglutination / drug effects
  • Hypersensitivity, Delayed / drug therapy
  • Hypersensitivity, Delayed / immunology
  • Immune System / drug effects*
  • Immunity, Cellular / drug effects
  • Immunity, Humoral / drug effects
  • Immunologic Factors / pharmacology*
  • Immunologic Factors / therapeutic use
  • Lipopolysaccharides / pharmacology*
  • Male
  • Neutrophils / drug effects
  • Neutrophils / immunology
  • Phagocytosis / drug effects
  • Pseudomonas aeruginosa
  • Rats
  • Rats, Wistar
  • Stress, Physiological / drug effects*
  • gamma-Aminobutyric Acid / analogs & derivatives*
  • gamma-Aminobutyric Acid / pharmacology
  • gamma-Aminobutyric Acid / therapeutic use


  • Immunologic Factors
  • Lipopolysaccharides
  • gamma-Aminobutyric Acid
  • 4-amino-3-phenylbutyric acid