Altered metabolism in cancer

BMC Biol. 2010 Jun 25;8:88. doi: 10.1186/1741-7007-8-88.


Cancer cells have different metabolic requirements from their normal counterparts. Understanding the consequences of this differential metabolism requires a detailed understanding of glucose metabolism and its relation to energy production in cancer cells. A recent study in BMC Systems Biology by Vasquez et al. developed a mathematical model to assess some features of this altered metabolism. Here, we take a broader look at the regulation of energy metabolism in cancer cells, considering their anabolic as well as catabolic needs. See research article:

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Animals
  • Cell Transformation, Neoplastic / genetics*
  • Citric Acid Cycle / genetics
  • Citric Acid Cycle / physiology
  • Energy Metabolism / physiology*
  • Glucose / metabolism*
  • Glycolysis / physiology
  • Humans
  • Models, Biological*
  • Neoplasms / metabolism*


  • Adenosine Triphosphate
  • Glucose