Manipulation of dendritic cell function by viruses

Curr Opin Microbiol. 2010 Aug;13(4):524-9. doi: 10.1016/j.mib.2010.06.002. Epub 2010 Jul 2.


Viruses manipulate the function of dendritic cells (DCs) to enhance their entry, spread, survival and transmission. This review summarises recently published work identifying how viruses alter the expression of receptors, antiviral molecules, disrupt signalling pathways, subvert trafficking pathways and even affect DC function via interactions with second or third cell types. Different viruses such as human immunodeficiency virus (HIV) and herpes viruses may have widely divergent and even opposite effects on DC function, determined by the need for transfer to a primary target cell, replication within the DC or various immunoevasive mechanisms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biological Transport / immunology
  • Dendritic Cells / immunology*
  • Dendritic Cells / metabolism
  • Dendritic Cells / virology*
  • Humans
  • Immune Evasion
  • Immunity, Innate
  • Receptors, Virus / immunology
  • Signal Transduction / immunology
  • Virus Diseases / immunology
  • Virus Diseases / virology*
  • Virus Internalization
  • Virus Replication / immunology
  • Viruses / immunology*


  • Receptors, Virus