Reactive oxygen species produced in mitochondria are involved in age-dependent changes of hematopoietic and mesenchymal progenitor cells in mice. A study with the novel mitochondria-targeted antioxidant SkQ1

Mech Ageing Dev. 2010 Jun;131(6):415-21. doi: 10.1016/j.mad.2010.06.003. Epub 2010 Jun 17.

Abstract

Lifelong treatment of mice with the effective mitochondria-targeted antioxidant SkQ1 [10-(6'-plastoquinonyl) decyltriphenylphosphonium] does not affect hematopoietic stem cells (HSC) and more differentiated hematopoietic progenitors but significantly decelerates age-dependent changes in peripheral blood. During the first 13 months, SkQ1 (0.9 or 28.8 nmol/kg day) prevents age-dependent myeloid shift (increase in the proportion of granulocytes and decrease in the proportion of lymphocytes). During the next year of treatment the effect disappears, and the hemogram of 2-year-old treated mice does not differ from the control. The number of mesenchymal stem cells (MSC) in the bone marrow does not change during 2 years of treatment with SkQ1, but the concentration of MSC progeny fibroblast colony-forming units (CFU-F) increases with dose of SkQ1. The concentration of CFU-F after 1 and 2 years treatment with SkQ1 is twice higher than in young mice. Our data indicate that the stromal environment of hematopoietic cells could be the primary target of age-dependent changes mediated by reactive oxygen species produced in mitochondria. The anti-aging effects of SkQ1 described here are in perfect agreement with the inhibitory effects of this antioxidant on aging observed in the other models.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / drug effects*
  • Animals
  • Antioxidants / pharmacology*
  • Female
  • Granulocytes / drug effects
  • Hematopoietic Stem Cells / drug effects*
  • Lymphocytes / drug effects
  • Mesenchymal Stem Cells / drug effects*
  • Mice
  • Mice, Inbred BALB C
  • Mitochondria / drug effects*
  • Plastoquinone / analogs & derivatives*
  • Plastoquinone / pharmacology
  • Reactive Oxygen Species / antagonists & inhibitors*
  • Reactive Oxygen Species / metabolism

Substances

  • 10-(6'-plastoquinonyl)decyltriphenylphosphonium
  • Antioxidants
  • Reactive Oxygen Species
  • Plastoquinone