The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets

Mol Cell. 2010 Jul 9;39(1):8-24. doi: 10.1016/j.molcel.2010.06.017.


The abundant nuclear enzyme PARP-1, a multifunctional regulator of chromatin structure, transcription, and genomic integrity, plays key roles in a wide variety of processes in the nucleus. Recent studies have begun to connect the molecular functions of PARP-1 to specific physiological and pathological outcomes, many of which can be altered by an expanding array of chemical inhibitors of PARP enzymatic activity.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cell Nucleus / enzymology*
  • Clinical Trials as Topic
  • DNA / metabolism
  • DNA Methylation / genetics
  • Humans
  • Models, Animal
  • Poly(ADP-ribose) Polymerase Inhibitors*
  • Poly(ADP-ribose) Polymerases / chemistry
  • Poly(ADP-ribose) Polymerases / metabolism*


  • Poly(ADP-ribose) Polymerase Inhibitors
  • DNA
  • Poly(ADP-ribose) Polymerases