Passage through the Golgi

Curr Opin Cell Biol. 2010 Aug;22(4):471-8. doi: 10.1016/ Epub 2010 Jun 3.


There are, in theory, several ways in which proteins may pass through the Golgi apparatus. Among these, the cisternal progression-maturation mode has gained broad consensus. However, there remain questions regarding the molecular mechanisms by which resident proteins are sorted from cargo and move backward to the proximal cisterna in synchrony with cisternal progression. In this short review, we discuss current questions about the organisation of trafficking to, through, and out of the Golgi apparatus, as well as the main approaches being developed to address such questions in model organisms including yeast, mammals and plants.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Endoplasmic Reticulum / metabolism
  • Golgi Apparatus / metabolism*
  • Humans
  • Models, Biological
  • Protein Transport
  • trans-Golgi Network / metabolism