The effect of vaccination on the transmission of Mycoplasma hyopneumoniae in pigs under field conditions

Vet J. 2011 Apr;188(1):48-52. doi: 10.1016/j.tvjl.2010.04.024. Epub 2010 Jun 1.


This study investigated the effect of vaccination against Mycoplasma hyopneumoniae on its transmission in nursery pigs under field conditions. Seventy-two pigs were randomly allocated at weaning into vaccinated (V) and non-vaccinated (NV) groups. Animals in the V group were vaccinated at 3 weeks of age with a commercial M. hyopneumoniae bacterin vaccine. Broncho-alveolar lavage fluid taken at weaning and at the end of the nursery period was assessed for the presence of M. hyopneumoniae by nested PCR, and the reproduction ratio of infection (R(n)) was calculated. The percentage of positive pigs in the V and NV groups was 14% and 36% at weaning, and 31% and 64% at the end of the nursery period, respectively. The R(n)-values for the V and NV groups were 0.71 and 0.56, respectively (P>0.05). The study indicates that vaccination does not significantly reduce the transmission of this respiratory pathogen.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Bacterial Vaccines / immunology*
  • Bronchoalveolar Lavage Fluid / microbiology
  • Disease Transmission, Infectious / prevention & control
  • Disease Transmission, Infectious / veterinary*
  • Female
  • Male
  • Mycoplasma hyopneumoniae / immunology*
  • Mycoplasma hyopneumoniae / isolation & purification
  • Pneumonia of Swine, Mycoplasmal / prevention & control*
  • Pneumonia of Swine, Mycoplasmal / transmission*
  • Polymerase Chain Reaction / veterinary
  • Swine
  • Weaning


  • Bacterial Vaccines