Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Jul;138(1):179-87.
doi: 10.1378/chest.09-2555.

Oxygen Therapy for Patients With COPD: Current Evidence and the Long-Term Oxygen Treatment Trial

Affiliations
Free PMC article
Review

Oxygen Therapy for Patients With COPD: Current Evidence and the Long-Term Oxygen Treatment Trial

James K Stoller et al. Chest. .
Free PMC article

Abstract

Long-term use of supplemental oxygen improves survival in patients with COPD and severe resting hypoxemia. However, the role of oxygen in symptomatic patients with COPD and more moderate hypoxemia at rest and desaturation with activity is unclear. The few long-term reports of supplemental oxygen in this group have been of small size and insufficient to demonstrate a survival benefit. Short-term trials have suggested beneficial effects other than survival in patients with COPD and moderate hypoxemia at rest. In addition, supplemental oxygen appeared to improve exercise performance in small short-term investigations of patients with COPD and moderate hypoxemia at rest and desaturation with exercise, but long-term trials evaluating patient-reported outcomes are lacking. This article reviews the evidence for long-term use of supplemental oxygen therapy and provides a rationale for the National Heart, Lung, and Blood Institute Long-term Oxygen Treatment Trial. The trial plans to enroll subjects with COPD with moderate hypoxemia at rest or desaturation with exercise and compare tailored oxygen therapy to no oxygen therapy.

Figures

Figure 1.
Figure 1.
Long-term oxygen therapy in Medical Research Council and National Institutes of Health controlled trials in men aged < 70 years, examining the fraction of subjects surviving compared to the time from randomization or duration of treatment. COT = continuous oxygen therapy; MRC = Medical Research Council; NOT = nocturnal oxygen therapy.

Similar articles

See all similar articles

Cited by 46 articles

See all "Cited by" articles

Publication types

MeSH terms

Feedback