Sestrins at the crossroad between stress and aging

Aging (Albany NY). 2010 Jun;2(6):369-74. doi: 10.18632/aging.100157.


Sestrins are a family of stress-inducible proteins that can function as antioxidants and as inhibitors of target of rapamycin complex 1. In this research perspective, we discuss the possible roles of Sestrins in diverse stress-induced patho-physiological contexts that can result in premature aging and age-related diseases. We suggest that Sestrins provide critical feedback regulation that adjust metabolic and stress responses to different environmental cues and evolutionary constraints.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Aging / physiology*
  • Animals
  • Feedback, Physiological / physiology
  • Heat-Shock Proteins / physiology*
  • Humans
  • Nuclear Proteins / physiology*
  • Stress, Physiological / physiology*


  • Heat-Shock Proteins
  • Nuclear Proteins