Sesquiterpenoids and other constituents from Senecio argunensis

Chem Pharm Bull (Tokyo). 2010 Jul;58(7):991-4. doi: 10.1248/cpb.58.991.

Abstract

Three new sesquiterpenoids, isodauc-7(14)-en-6alpha,10beta-diol (1), 10beta-hydroxyisodauc-6-en-14-al (2), and (7S(*))-opposit-4(15)-en-1beta,7-diol (4), along with ten known compounds have been isolated from the aerial parts of Senecio argunensis. Their structures were established by means of detailed spectroscopic analysis including IR, HR-MS, and 1D NMR and 2D NMR data. The sesquiterpenoids were assayed against Escherichia coli, Staphylococcus aureus and Bacillus subtilis. Compounds 4 exhibited weak antibacterial activity against Escherichia coli and Bacillus subtilis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Molecular Conformation
  • Plant Extracts / chemistry
  • Senecio / chemistry*
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology

Substances

  • (7S*)-opposit-4(15)-en-1beta ,7-diol
  • 10beta-hydroxyisodauc-6-en-14-al
  • Anti-Bacterial Agents
  • Plant Extracts
  • Sesquiterpenes
  • isodauc-7(14)-en-6alpha,10beta-diol