Sophorolipid production by Candida bombicola on oils with a special fatty acid composition and their consequences on cell viability

Biotechnol Lett. 2010 Oct;32(10):1509-14. doi: 10.1007/s10529-010-0323-8. Epub 2010 Jul 6.


Sophorolipids production by the yeast Candia bombicola is most favourable when glucose is used as a carbon source in combination with a hydrophobic carbon source such as a common vegetable oil. Most vegetable oils are comprised of C16-C18 fatty acids, an ideal range for sophorolipid production. The use of oils with either shorter or longer fatty acids, such has coconut oil or meadowfoam oil, respectively, was evaluated. Such oils did not contribute to enhanced sophorolipid production when compared to cultures run on glucose as the sole carbon source. Moreover, a toxic effect of medium-chain fatty acids towards stationary C. bombicola cells was demonstrated.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Candida / metabolism
  • Candida / physiology*
  • Culture Media / chemistry
  • Fatty Acids / metabolism
  • Glucose / metabolism
  • Lipid Metabolism*
  • Microbial Viability*
  • Plant Oils / metabolism


  • Culture Media
  • Fatty Acids
  • Plant Oils
  • Glucose