Ataxia-telangiectasia mutated kinase (ATM) as a central regulator of radiation-induced DNA damage response

Acta Medica (Hradec Kralove). 2010;53(1):13-7. doi: 10.14712/18059694.2016.57.

Abstract

Ataxia-telangiectasia mutated kinase (ATM) is a DNA damage-inducible protein kinase, which phosphorylates plethora of substrates participating in DNA damage response. ATM significance for the cell faith is undeniable, since it regulates DNA repair, cell-cycle progress, and apoptosis. Here we describe its main signalling targets and discuss its importance in DNA repair as well as novel findings linked to this key regulatory enzyme in the terms of ionizing radiation-induced DNA damage.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Ataxia Telangiectasia / genetics
  • Ataxia Telangiectasia Mutated Proteins
  • Cell Cycle / physiology
  • Cell Cycle Proteins / genetics*
  • Cell Cycle Proteins / physiology
  • DNA Damage / radiation effects*
  • DNA Repair / physiology*
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / physiology
  • Humans
  • Mutation*
  • Protein-Serine-Threonine Kinases / genetics*
  • Protein-Serine-Threonine Kinases / physiology
  • Tumor Suppressor Proteins / genetics*
  • Tumor Suppressor Proteins / physiology

Substances

  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • Tumor Suppressor Proteins
  • ATM protein, human
  • Ataxia Telangiectasia Mutated Proteins
  • Protein-Serine-Threonine Kinases