Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1991 Jun;32(6):604-6.
doi: 10.1136/gut.32.6.604.

Prospective Clinical and Manometric Study Comparing Pneumatic Dilatation and Sublingual Nifedipine in the Treatment of Oesophageal Achalasia

Affiliations
Free PMC article
Clinical Trial

Prospective Clinical and Manometric Study Comparing Pneumatic Dilatation and Sublingual Nifedipine in the Treatment of Oesophageal Achalasia

G Coccia et al. Gut. .
Free PMC article

Abstract

A study was carried out in 30 patients affected by a mild or moderate degree of oesophageal achalasia to compare the clinical and manometric effects of sublingual nifedipine and pneumatic dilatation. Sixteen patients were dilated twice with Rider-Moeller dilators and 14 were treated with sublingual nifedipine 10-20 mg 30 minutes before meals. A manometric evaluation was performed before and six months after starting treatment. The clinical evaluation (according to Vantrappen's criteria) was performed every three months for a mean follow up of 21 months. In both groups of patients a significant (p less than 0.001) fall in lower oesophageal sphincter pressure was observed after treatment and excellent or good clinical results were observed in 75% of dilated patients and in 77% of patients treated with nifedipine. One patient could not tolerate nifedipine. No complications were observed after dilatation. It is concluded that longterm treatment with sublingual nifedipine and pneumatic dilatation are equally effective in the treatment of oesophageal achalasia of mild or moderate degree.

Comment in

Similar articles

See all similar articles

Cited by 15 articles

  • 2019 Seoul Consensus on Esophageal Achalasia Guidelines.
    Jung HK, Hong SJ, Lee OY, Pandolfino J, Park H, Miwa H, Ghoshal UC, Mahadeva S, Oshima T, Chen M, Chua ASB, Cho YK, Lee TH, Min YW, Park CH, Kwon JG, Park MI, Jung K, Park JK, Jung KW, Lim HC, Jung DH, Kim DH, Lim CH, Moon HS, Park JH, Choi SC, Suzuki H, Patcharatrakul T, Wu JCY, Lee KJ, Tanaka S, Siah KTH, Park KS, Kim SE; Korean Society of Neurogastroenterology and Motility. Jung HK, et al. J Neurogastroenterol Motil. 2020 Apr 30;26(2):180-203. doi: 10.5056/jnm20014. J Neurogastroenterol Motil. 2020. PMID: 32235027 Free PMC article. Review.
  • Descriptive Rules for Achalasia of the Esophagus, June 2012: 4th Edition.
    Japan Esophageal Society. Japan Esophageal Society. Esophagus. 2017;14(4):275-289. doi: 10.1007/s10388-017-0589-1. Epub 2017 Sep 5. Esophagus. 2017. PMID: 28983228 Free PMC article. No abstract available.
  • Therapeutic options in oesophageal dysphagia.
    Tack J, Zaninotto G. Tack J, et al. Nat Rev Gastroenterol Hepatol. 2015 Jun;12(6):332-41. doi: 10.1038/nrgastro.2015.45. Epub 2015 Mar 31. Nat Rev Gastroenterol Hepatol. 2015. PMID: 25824996 Review.
  • Comparison of topical nifedipine with oral nifedipine for treatment of anal fissure: a randomized controlled trial.
    Golfam F, Golfam P, Golfam B, Pahlevani P. Golfam F, et al. Iran Red Crescent Med J. 2014 Aug;16(8):e13592. doi: 10.5812/ircmj.13592. Epub 2014 Aug 5. Iran Red Crescent Med J. 2014. PMID: 25389477 Free PMC article.
  • Endoscopic approach to achalasia.
    Müller M, Eckardt AJ, Wehrmann T. Müller M, et al. World J Gastrointest Endosc. 2013 Aug 16;5(8):379-90. doi: 10.4253/wjge.v5.i8.379. World J Gastrointest Endosc. 2013. PMID: 23951393 Free PMC article.
See all "Cited by" articles

References

    1. Surg Gynecol Obstet. 1971 Sep;133(3):482-4 - PubMed
    1. Ann Intern Med. 1956 Aug;45(2):207-15 - PubMed
    1. Gut. 1989 Jun;30(6):768-73 - PubMed
    1. Gut. 1989 Mar;30(3):299-304 - PubMed
    1. Gut. 1986 Aug;27(8):986-9 - PubMed
Feedback